Brain cancer can occur for one of many reasons but how exactly does this condition progress, one on the outside has to wonder? Well, most of it has to do with the presence of enzymes and how they are able to trigger the condition to become more severe with time. This is the case for glioblastoma, in particular, which is regarded as the most aggressive form of the cancer in question. Can a new method come into effect, though, for the sake of halting a particular enzyme?
According to a Futurity article, it appears as though this will be the case. A new "backdoor" approach has been seen in order to help this form of brain cancer. Basically, it will be able to halt an enzyme that is responsible for the progression of glioblastoma, which is reason enough for organizations along the lines of Voices against Brain Cancer to bring their focus on it. What are the specifics behind this, though, and how was the study carried through? The details are quite interesting, to say the least.
The enzyme that I would like to focus on in regards to this study goes by the name of phospholipase D. While it is one that has been connected to brain cancer, it is prudent to make note of how it is connected to other forms of cancer, gastric being just one instance to consider. PLD also comes into play for the sake of regulating Akt. For those who are not in the know, Akt is another enzyme that specifically plays into the growth and progression of cancer.
PLD was given focus in this regard and it was done during a study that involved afflicted mice. Judging by the information previously stated, one would imagine that blocking the actions of Akt would prove to be of great assistance to the issue here. However, the article said that if it is blocked, the body stands a great chance of triggering an exaggerated immune response or diabetic symptoms. Akt has to be targeted, of course, but there should still be a level of urgency taken into account.
Professor Craig Lindsley alluded to the idea that the isoform most closely related to Akt could be focused on without the patient being harmed. After all, if Akt is not given the chance to be activated, it will lead to cancerous cells dying out without leaving the patients with implications that could be seen in the long term. When considering any type of research, this should be paramount. With this in mind, I have to believe that the focus given on particular enzymes houses great potential.
According to a Futurity article, it appears as though this will be the case. A new "backdoor" approach has been seen in order to help this form of brain cancer. Basically, it will be able to halt an enzyme that is responsible for the progression of glioblastoma, which is reason enough for organizations along the lines of Voices against Brain Cancer to bring their focus on it. What are the specifics behind this, though, and how was the study carried through? The details are quite interesting, to say the least.
The enzyme that I would like to focus on in regards to this study goes by the name of phospholipase D. While it is one that has been connected to brain cancer, it is prudent to make note of how it is connected to other forms of cancer, gastric being just one instance to consider. PLD also comes into play for the sake of regulating Akt. For those who are not in the know, Akt is another enzyme that specifically plays into the growth and progression of cancer.
PLD was given focus in this regard and it was done during a study that involved afflicted mice. Judging by the information previously stated, one would imagine that blocking the actions of Akt would prove to be of great assistance to the issue here. However, the article said that if it is blocked, the body stands a great chance of triggering an exaggerated immune response or diabetic symptoms. Akt has to be targeted, of course, but there should still be a level of urgency taken into account.
Professor Craig Lindsley alluded to the idea that the isoform most closely related to Akt could be focused on without the patient being harmed. After all, if Akt is not given the chance to be activated, it will lead to cancerous cells dying out without leaving the patients with implications that could be seen in the long term. When considering any type of research, this should be paramount. With this in mind, I have to believe that the focus given on particular enzymes houses great potential.
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If you'd like to learn more about efforts to elevate awareness for brain cancer, please visit Voices against Brain Cancer.
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